Publications and evidence
Work that stands up to scrutiny.
Prima Nexus is dedicated to helping scientists and researchers with reliable, quality-controlled products and services. The programs we coordinate have supported more than 100 papers published in peer-reviewed SCI journals. A selection is listed below, each linked to its published record.
161
Papers supported in peer-reviewed journals
40+
Institutions supported
14,000+
Tests delivered
8
Core research domains
Publication library
Peer-reviewed work, by research area.
Grouped by research area, from oncology and bone health to immunology, metabolic, neuroscience and infectious disease. The platform that generated the data is noted under each title.
161 publications
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Research area
Metabolic health and nutrition 27
Diabetes, obesity and metabolic syndrome, from functional food and probiotic trials to maternal obesity and diabetic animal models.
Encapsulated oil palm phenolics lower blood pressure and improve antioxidant status in healthy adults: a phase one trial2025 · Trial product encapsulation
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Effect of nipa palm (Nypa fruticans Wurmb.) vinegar on the incretin hormones and intestinal glucose transporters in type 2 diabetes mellitus rat model2025 · Clinical biochemistry
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Safety and efficacy of oil palm phenolic supplementation in improving lipid profile among hyperlipidemic adults: a phase 2, randomized, double-blind, placebo-controlled clinical trial2023 · Clinical trial (CRO)
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The Mechanism of Kelulut Honey in Reversing Metabolic Changes in Rats Fed with High-Carbohydrate High-Fat Diet2023 · Multiplex immunoassay · ELISA
DOI ↗Induction of a single dose of streptozotocin (50 mg) in rat model causes insulin resistance with type 2 diabetes mellitus2023 · Histology and IHC
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A Phase I, Randomized, Double-Blind, Placebo-Controlled Clinical Trial to Evaluate the Safety and Tolerance of Oil Palm Phenolics (OPP) in Healthy Volunteers2022 · Clinical trial (CRO)
DOI ↗The Roles of Probiotics in the Gut Microbiota Composition and Metabolic Outcomes in Asymptomatic Post-Gestational Diabetes Women: A Randomized Controlled Trial2022 · Multiplex immunoassay
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The Prebiotic Potential of Geraniin and Geraniin-Enriched Extract against High-Fat-Diet-Induced Metabolic Syndrome in Sprague Dawley Rats2022 · Multiplex immunoassay · ELISA
DOI ↗Methanolic Extract of Piper sarmentosum Attenuates Obesity and Hyperlipidemia in Fructose-Induced Metabolic Syndrome Rats2021 · Clinical biochemistry
DOI ↗In vivo study of homoeopathic preparation of Gymnema sylvestre mother tincture, 30C and 200C on streptozotocin-induced diabetic rats2021 · In vivo animal study
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Short-Term Intake of Yellowstripe Scad versus Salmon Did Not Induce Similar Effects on Lipid Profile and Inflammatory Markers among Healthy Overweight Adults despite Their Comparable EPA+DHA Content2021 · Multiplex immunoassay
DOI ↗Gut Microbiota Signature Among Asian Post-gestational Diabetes Women Linked to Macronutrient Intakes and Metabolic Phenotypes2021 · Multiplex immunoassay
DOI ↗Orthosiphon stamineus as a potential antidiabetic drug in maternal hyperglycemia in streptozotocin-induced diabetic rats2019 · Clinical biochemistry · ELISA
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Neuroscience and neurodegeneration 16
Alzheimer's, cognitive decline, depression and neuroinflammation, from neural stem cells and rat models to clinical trials.
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Selective elimination of amyloid-β-induced senescent neuroblastoma cells by Moringa oleifera leaf extract2026 · ELISA
DOI ↗Antidepressant-like Effects of Orthosiphon stamineus: Integrated Evidence from In Silico, In Vitro, and a Reserpine-Induced Depression Model2026 · ELISA · Histology and IHC
DOI ↗Dysregulation of REST and its target genes impacts the fate of neural progenitor cells in down syndrome2025 · Western blot
DOI ↗Dietary menhaden fish oil supplementation suppresses lipopolysaccharide-induced neuroinflammation and cognitive impairment in diabetic rats2024 · Laboratory animals
DOI ↗Tocotrienol-rich fraction (TRF) protects against retinal cell apoptosis and preserves visual behavior in rats with streptozotocin-induced diabetic retinopathy2024 · ELISA · Real-time PCR
DOI ↗Identifying the stability of housekeeping genes to be used for the quantitative real-time PCR normalization in retinal tissue of streptozotocin-induced diabetic rats2024 · Real-time PCR
DOI ↗Neuroprotection Against NMDA-Induced Retinal Damage by Philanthotoxin-343 Involves Reduced Nitrosative Stress2021 · ELISA · Histology and IHC
DOI ↗Serum Metabolomics Profiling of Commercially Mixed Functional Foods, Effects in Beta-Amyloid Induced Rats Measured Using 1H NMR Spectroscopy2020 · In vivo animal study
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Cardiovascular health 16
Coronary artery disease biomarkers, atherosclerosis and endothelial models, hypertension and heart failure.
Matrix Metalloproteinases and Cardiac Remodelling in Smokers with Acute Coronary Syndrome2026 · ELISA
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Functional Characterization of Putative Novel MicroRNA-1133 in the Antioxidant Effects of Metformin in Hyperglycemia-Induced Endothelial Cells2026 · Cell culture reagents
DOI ↗Regulatory Role of miR-196a-5p in Angiogenesis-Related Markers in Endothelial Cells Exposed to Hypertensive Pregnancies2026 · Cell culture reagents
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Modulation of atherogenesis biomarkers by PCSK9 inhibitors in Lp(a)-stimulated human coronary artery endothelial cells2025 · ELISA · QuantiGene Plex
DOI ↗Anti-atherogenic mechanism of ethanol extract of Christia vespertilionis (L.f.) Bakh. F. Leaves in vitro2024 · Western blot
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PCSK9 Inhibitors Reduce PCSK9 and Early Atherogenic Biomarkers in Stimulated Human Coronary Artery Endothelial Cells2023 · ELISA · QuantiGene Plex
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Safety and Efficacy of Dietary Epigallocatechin Gallate Supplementation in Attenuating Hypertension via Its Modulatory Activities on the Intrarenal Renin-Angiotensin System in Spontaneously Hypertensive Rats2022 · Biochemical assay kits · Clinical biochemistry
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Infectious and tropical disease 14
Dengue, malaria and SARS-CoV-2 research, from patient cytokines and genomic surveillance to vaccine candidates.
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Amplifying immune responses via a parenteral prime-intranasal boost strategy using a lipidated chitosan nanoparticle-based multi-epitope COVID-19 vaccine2026 · Multiplex immunoassay
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Genomic evidence links human dengue cases with undetermined serotypes to sylvatic lineages2025 · Next-generation sequencing
DOI ↗Unraveling potential gene biomarkers for dengue infection through RNA sequencing2024 · RNA sequencing
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Virus-like Particles of Nodavirus Displaying the Receptor Binding Domain of SARS-CoV-2 Spike Protein: A Potential VLP-Based COVID-19 Vaccine2023 · Multiplex immunoassay · ELISA
DOI ↗Resurgence of Dengue Virus Serotype 4 in Malaysia: A Comprehensive Clinicodemographic and Genomic Analysis2023 · Next-generation sequencing
DOI ↗SARS-CoV-2 genomic surveillance in Malaysia: displacement of B.1.617.2 with AY lineages as the dominant Delta variants and the introduction of Omicron during the fourth epidemic wave2022 · Next-generation sequencing
DOI ↗Chimeric Virus-Like Particles of Prawn Nodavirus Displaying Hepatitis B Virus Immunodominant Region: Biophysical Properties and Cytokine Response2021 · Multiplex immunoassay
DOI ↗Effect of freeze-dried Carica papaya leaf juice on inflammatory cytokines production during dengue virus infection in AG129 mice2019 · Multiplex immunoassay
DOI ↗Cytokine Expression Profile of Dengue Patients at Different Phases of Illness2012 · Multiplex immunoassay
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Reproductive health 14
Male and female reproductive health, from fertility and hormone models to pregnancy cohorts and menopause trials.
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Testicular Heat-Shock Protein Expression in Rats Following 3.5 GHz and 24 GHz RF-EMF Exposure2026 · Histology and IHC · Western blot
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Effect of Eurycoma longifolia water extract (Physta®) on menopausal quality of life and mood states2025 · Clinical biochemistry
DOI ↗Exploring edible bird nest's potential in mitigating Wi-Fi's impact on male reproductive health2024 · ELISA · Real-time PCR
DOI ↗Protective Role of Kelulut Honey against Toxicity Effects of Polystyrene Microplastics on Morphology, Hormones, and Sex Steroid Receptor Expression in the Uterus of Rats2023 · ELISA · Real-time PCR
DOI ↗Maternal melatonin levels and temporal dietary intake: results from MY-CARE cohort study2023 · ELISA
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Modulation of vulvovaginal atrophy (VVA) by Gelam honey in bilateral oophorectomized rats2023 · Real-time PCR
DOI ↗Kelulut Honey Ameliorates Oestrus Cycle, Hormonal Profiles, and Oxidative Stress in Letrozole-Induced Polycystic Ovary Syndrome Rats2022 · ELISA · Biochemical assay kits
DOI ↗Kelulut Honey Improves Folliculogenesis, Steroidogenic, and Aromatase Enzyme Profiles and Ovarian Histomorphology in Letrozole-Induced Polycystic Ovary Syndrome Rats2022 · Real-time PCR
DOI ↗Kelulut Honey Regulates Sex Steroid Receptors in a Polycystic Ovary Syndrome Rat Model2022 · Real-time PCR
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Bone health and musculoskeletal 13
Osteoporosis models, bone and cartilage gene expression, chondrosarcoma and muscle ageing.
Correlation between oxidative stress and inflammation with metabolomics profile in skeletal muscle of ageing animal model and its modulation by tocotrienol-rich fraction2026 · Multiplex immunoassay
DOI ↗Bioactive-Rich Piper sarmentosum Aqueous Extract Mitigates Osteoarthritic Pathology by Enhancing Anabolic Activity and Attenuating NO-Driven Catabolism in Human Chondrocytes2026 · Cell culture reagents
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Transcriptomic Analysis of the Anticancer Effects of Annatto Tocotrienol, Delta-Tocotrienol and Gamma-Tocotrienol on Chondrosarcoma Cells2022 · RNA sequencing
DOI ↗Spirulina supplementation improves bone structural strength and stiffness in streptozocin-induced diabetic rats2022 · Histology and IHC
DOI ↗Establishing SW1353 Chondrocytes as a Cellular Model of Chondrolysis2021 · Flow cytometry
MDPI ↗The Effects of Tocotrienol on Bone Peptides in a Rat Model of Osteoporosis Induced by Metabolic Syndrome: The Possible Communication between Bone Cells2019 · Multiplex immunoassay
DOI ↗Effects of annatto-derived tocotrienol supplementation on osteoporosis induced by testosterone deficiency in rats2014 · QuantiGene Plex
PubMed ↗Labisia pumila regulates bone-related genes expressions in postmenopausal osteoporosis model2013 · QuantiGene Plex
PubMed ↗Eurycoma longifolia upregulates osteoprotegerin gene expression in androgen-deficient osteoporosis rat model2012 · QuantiGene Plex
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Haematology, immunology and inflammation 12
Cytokine profiling, allergy, psoriasis, dermatitis, gout and leukaemia studies.
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Mitochondrial apoptosis and G0/G1-phase blockade: key mechanisms underlying triphenyltin(IV) dithiocarbamate-mediated cytotoxicity in human lymphoblastic leukemia cells2025 · Western blot
DOI ↗The role of probiotics in improving menstrual health in women with primary dysmenorrhoea: A randomized, double-blind, placebo-controlled trial (the PERIOD study)2024 · Multiplex immunoassay
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Extracts of Andrographis paniculata (Burm.f.) Nees Leaves Exert Anti-Gout Effects by Lowering Uric Acid Levels and Reducing Monosodium Urate Crystal-Induced Inflammation2022 · Multiplex immunoassay
DOI ↗Anti-inflammatory evaluation of Scurrula ferruginea (Jack) Danser parasitizing on Tecoma stans (L.) HBK in LPS/IFN-γ-induced RAW 264.7 macrophages2021 · Multiplex immunoassay
DOI ↗Circulating cytokines and small molecules follow distinct expression patterns in acute myeloid leukaemia2017 · Multiplex immunoassay
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Oncology, gastrointestinal 9
Colorectal and colonic cancer work, including chemosensitivity, apoptosis and serum marker studies.
In vitro Anti-colorectal Cancer Potential of the Medicinal Mushroom Ganoderma neo-japonicum Imazeki in Hyperglycemic Condition: Impact on Oxidative Stress, Cell Cycle and Apoptosis2022 · Flow cytometry
PubMed ↗In vitro and in silico anticancer evaluation of a medicinal mushroom, Ganoderma neo-japonicum Imazeki, against human colonic carcinoma cells2021 · Flow cytometry · LC-MS
PubMed ↗L1CAM, CA9, KLK6, HPN, and ALDH1A1 as Potential Serum Markers in Primary and Metastatic Colorectal Cancer Screening2020 · Multiplex immunoassay
DOI ↗Rosiglitazone enhances the apoptotic effect of 5-fluorouracil in colorectal cancer cells with high-glucose-induced glutathione2020 · Flow cytometry
PubMed ↗A randomized double-blind placebo-controlled trial of probiotics in post-surgical colorectal cancer2019 · Multiplex immunoassay
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Oncology, breast, cervical and skin 9
Solid tumour studies covering gene expression, angiogenesis, natural product cytotoxicity, drug delivery and a breast cancer vaccine model.
Apoptosis and anti-migratory effects of Methyl gallate combined with Cisplatin in human breast cancer (MCF-7) cells2025 · Biochemical assay kits
PubMed ↗SF1, a Standardised Fraction from Clinacanthus nutans Modulates Notch1 Signalling in Cervical Cancer Stem-Like Cells2025 · Western blot
DOI ↗Combination of Talazoparib and Calcitriol Enhanced Anticancer Effect in Triple-Negative Breast Cancer Cell Lines2022 · Flow cytometry
DOI ↗HER2/neu-Based Peptide Vaccination-Pulsed with B-Cell Epitope Induced Efficient Prophylactic and Therapeutic Antitumor Activities in TUBO Breast Cancer Mice Model2021 · Multiplex immunoassay
DOI ↗Induction of Apoptotic Mechanism by Streblus asper Root Extract on Cervical Cancer Using in Vitro and in Vivo Models2019 · Protein array
PDF ↗Assessment of cytotoxicity potency of paclitaxel in combination with Clinacanthus nutans extracts on human MDA-MB-231 breast cancer cells2018 · Multiplex immunoassay
Scholar ↗Novel fish oil-based bigel system for controlled drug delivery and its influence on immunomodulatory activity of imiquimod against skin cancer2016 · QuantiGene Plex
Springer ↗Palm tocotrienols decrease levels of pro-angiogenic markers in human umbilical vein endothelial cells (HUVEC) and murine mammary cancer cells2012 · QuantiGene Plex
PMC ↗Expression and mutational analysis of GATA3 in Malaysian breast carcinomas2010 · QuantiGene Plex
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Natural product safety and toxicology 5
Antimutagenic, antioxidant, oxidative stress and acute toxicity evaluation of plant preparations.
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Therapeutic potential of Tetracera scandens on oxidative stress using aspartame-induced oxidative stress rat model and toxicity assessment2025 · Laboratory animals
DOI ↗Antimutagenic, Cytoprotective and Antioxidant Properties of Ficus deltoidea Aqueous Extract In Vitro2021 · Flow cytometry
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Nanomedicine and drug delivery 5
Gold-conjugated calcium carbonate nanoparticles for drug delivery and cell imaging.
Topical 915-3985 MHz Microwave Sweep-Assisted Retention of Nanoemulsified α-Tocopherol for Dermatitis Treatment2026 · Histology and IHC
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Fluorescent imaging and bio-cellular uptake assessment of gold-near infrared dye conjugated cockle shell calcium carbonate nanoparticle2024 · Reagent supply
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Eye health 4
Retinal protection, optic nerve injury and diabetic eye disease models.
N-Methyl-d-Aspartate-Induced Excitotoxicity and Its Impact on the Renin-Angiotensin System in Retinal Tissue2025 · ELISA
DOI ↗Role of TGF-β1/SMADs signalling pathway in resveratrol-induced reduction of extracellular matrix deposition by dexamethasone-treated human trabecular meshwork cells2024 · ELISA · Real-time PCR
DOI ↗Tocotrienol-rich fraction reduces retinal inflammation and angiogenesis in rats with streptozotocin-induced diabetes2023 · ELISA · Real-time PCR
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Oncology, other cancers 4
Oral, renal and other solid tumour studies of cell death, blood vessels and drug response.
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Digestive, kidney and liver health 4
Stomach, liver and kidney protection studies in animal and cell models.
Hepatic and renal effects of oral stingless bee honey in a streptozotocin-induced diabetic rat model2024 · ELISA
DOI ↗Piper sarmentosum Roxb. methanolic extract prevents stress-induced gastric ulcer by modulating oxidative stress and inflammation2023 · QuantiGene Plex
DOI ↗Etlingera elatior Flower Aqueous Extract Protects against Oxidative Stress-Induced Nephropathy in a Rat Model of Type 2 Diabetes2022 · ELISA · Biochemical assay kits
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Regenerative medicine and cell therapy 3
Paracrine factor synthesis under autologous serum supplementation.
Synthesis and characterization of electroactive chitosan/gelatin/PEDOT:PSS hydrogels with mixed ionic-electronic conductivity for potential wound healing applications2026 · Cell culture reagents
DOI ↗Single high-dose intravenous injection of Wharton's jelly-derived mesenchymal stem cell exerts protective effects in a rat model of metabolic syndrome2024 · ELISA · Multiplex immunoassay
DOI ↗Autologous serum supplement favours in vitro regenerative paracrine factors synthesis2017 · Multiplex immunoassay
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Human physiology and wellbeing 2
Circadian, stress and sleep markers, from a real Malaysian workplace to a supplement trial.
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Skin health and wound healing 2
Wound healing and skin pigmentation studies.
Antioxidant, Wound Healing Potential and In Silico Assessment of Naringin, Eicosane and Octacosane2023 · Histology and IHC
DOI ↗Effect of Chicken Egg White-Derived Peptide and Hydrolysates on Abnormal Skin Pigmentation during Wound Recovery2022 · Real-time PCR · ELISA
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Oral and dental health 1
Oral biofilm and fungal infection models.
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Respiratory health 1
Airway inflammation and remodelling models.
Each title links to the publisher, PubMed, or repository record. This selection is illustrative of work supported across our platforms; a fuller list is available on request.
They run trials and experiments in a meticulous way for each kit, with results generated quickly and clearly. It eased up my time for data analysis.
Dr. Lelia Tay · PPUKMGreat service, quick delivery, the order was constantly updated and I was well informed. Data and results were consistent.
Dr. Priyadarshni Bindal · Universiti MalayaCase studies
The stories behind some of these papers.
From Safety to Efficacy: Supporting the Clinical Trials of Oil Palm Phenolics
A Universiti Kebangsaan Malaysia team, funded by the Malaysian Palm Oil Board, took a palm-derived supplement through Phase I and Phase II trials. Prima Nexus was the contract research organisation for both, handling the blinded trial capsules.
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Measuring Inflammation in Ageing Muscle With the PrimePlex Multiplex Service
A UKM biochemistry team studied whether tocotrienols protect ageing muscle. Prima Nexus measured the inflammatory markers IL-6 and TNF-alpha with its PrimePlex multiplex assay service.
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Can Office Lighting Give Workers a Morning Boost? Measuring Melatonin for a UPM Study
Architecture researchers at Universiti Putra Malaysia tested dynamic lighting in a windowless office. Prima Nexus ran the urinary melatonin ELISA that tracked the body's response.
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