NTRODUCTION
Alzheimer’s disease, stroke and glaucoma are the most common age-dependent neurodegenerative disease, which altogether affect over 110 million people worldwide. In 2015, there were approximately 29.8 million people worldwide with Alzheimer’s disease. Glaucoma is second leading cause of irreversible blindness and according to the World Health Organization about 80 million people will have glaucoma by 2020. Stroke is the number two cause of death in the world as stated by the WHO data in 2012. Annually, 15 million people worldwide suffer a stroke.
Currently, only four drugs are approved for alleviating symptoms in AD patients, and no new therapy has been approved for AD since 2003. Other neurodegenerative diseases such as stroke and glaucoma also lack effective therapies. Hence, finding cure for these neurodegenerative diseases is urgent and various approaches should be actively pursued. Hence, investigations into the knowledge of pathophysiological processes and development of safe and effective therapeutic measures to reduce morbidity due to these diseases are of prime importance. However, experimental methods used to study neuroprotection and prevention of the neurodegeneration are not widely known. Hence we propose to organize a workshop to demonstrate common procedures undertaken to carry out research in investigations related to neurodegeneration and neuroprotection.
OBJECTIVES
To enhance the knowledge of participants regarding commonly used procedures in investigations related to neurodegeneration and neuroprotection in animals.
To provide hands-on experience of commonly used procedures in investigations related to neurodegeneration and neuroprotection in animals.
SUMMARY OF WORKSHOP
Workshop: |
NEUROSCIENCE WORKSHOP SERIES 2: EXPERIMENTAL MODELS OF NEURODEGENERATIVE DISEASES |
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Duration: |
3 days |
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Proposed dates: |
21st – 23rd November 2018 (WED to FRI) |
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Venue: |
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Target No. of participants: |
20 pax (minimum) |
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Modes of training: |
Lectures, practical sessions |
TARGETED PARTICIPANTS
Postgraduates in medicine, pharmacy, health sciences and biomedical research.
Young investigators in medicine, pharmacy, health sciences and biomedical research.
REGISTRATION FEE
Non-UiTM |
UiTM |
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(3 days workshop) |
1,000 MYR per person |
800 MYR per person |
(2 days workshop) |
700 MYR per person |
600 MYR per person |
(1 day workshop) |
500 MYR per person |
400 MYR per person |
ORGANIZING COMMITTEE
Advisor |
A/P Dr Fazah Akhtar Hanapiah |
Chairperson |
A/P Dr Igor Iezhitsa |
Co-Chairs |
A/P Dr Renu Agarwal, Dr Rosfaiizah Siran |
Secretary |
Dr Syed Baharom Syed Ahmad Fuad |
Treasurer |
Noor Azliza Wani Abd. Aziz Dr Siti Norsyafika Kamarudin |
Registration and Publicity |
Dr Norhafiza Razali Mr Mohd Yazrie Yacob |
Food and Technical |
Dr Nurul Alimah Abdul Nasir Mr Mohamad Razif Mohamad Taib Mr Azhar Ahmad |
Other members |
Mr Mohd Aizuddin Mohd Lazaldin (Registration) Adrian Julian Marcus (Registration) Lidawani Lambuk (Registration) Natasha Najwa Nor Arfuzir (Certificates & Tokens) Azliana Jusnida Ahmad Jafri (Certificates & Tokens) Nurul Ainsya Bakry (Materials & Handouts) Normie Aida Mohd Nasir (Materials & Handouts) |
DAY 1 ANIMAL MODELS FOR STROKE RESEARCH (Wed 21/11/2018)
(Anchored and chaired by Dr Rosfaiizah Binti Siran and Dr Syed Baharom)
Day 1: |
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TIME |
PROGRAMME |
SPEAKERS |
8.00 AM - 08.30 AM |
Registration of participants |
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8.30 AM - 08.40 AM |
Welcoming Address and Opening Ceremony |
Assoc Prof Dr Fazah Akhtar Hanapiah, Deputy Dean, Faculty of Medicine, UiTM |
8.40 AM - 09.00 AM |
Welcome address and introduction |
Dr Rosfaiizah Siran MBBChBAO (UCC), PhD (USM) |
09.00 AM – 09.45 AM |
Animal models of stroke: translational potential at present and future |
Dr Andrean Husin MBBChBAO (UCC), MSurg (Neurosurgery) (USM) |
09.45 AM – 10.30 AM |
The use of animal models for stroke research |
Dr Syed Baharom Syed Mohd Fuad MBBS (IMU), MSc (UM), PhD(Melbourne) |
10.30 – 11.00 |
Coffee Break and Poster Viewing |
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11.00 AM – 11.45 AM |
Challenges in experimental animal models for stroke research |
Dr Rosfaiizah Siran MBBChBAO (UCC), PhD (USM) |
11.45 AM – 12.30 AM |
Video: Middle cerebral artery occlusion for ischemic stroke |
Dr Nik Nasihah binti Nik Ramli PhD (UiTM) |
12.30 – 14.00 |
Lunch |
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14:00 AM – 15:30 AM |
Demonstration: Ischemic stroke |
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15:30 AM – 16:30 AM |
Demonstration: Haemorrhagic stroke |
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16.30 – 17.00 |
CLOSING REMARKS, TEA AND END OF DAY 2 |
DAY 2 NON-TRANSGENIC MODELS OF ALZHEIMER'S DISEASE (Thu 22/11/2018)
(Anchored and chaired by Dr Igor Iezhitsa)
Day 2: |
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TIME |
TITLE |
SPEAKERS / FACILITATORS |
08.00 AM – 08:30 AM |
Registration of participants |
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08.30 AM – 08.40 AM |
Welcome address and introduction |
A/P Dr Igor Iezhitsa Ph.D. (Russia), Dr. Sci. Biol. (Russia) |
08.40 AM – 09.20 AM |
Chemical-induced animal models of Alzheimer’s disease |
Prof. Dato' Dr Abu Bakar Abdul Majeed |
09.20 AM – 10.00 AM |
Behavioral tasks commonly used for testing hippocampal-dependent cognition |
A/P Dr Igor Iezhitsa Ph.D. (Russia), Dr. Sci. Biol. (Russia) |
10.00 AM – 10.30 AM |
Animal handling, animal care and selection for animal behavioural studies |
Dr Raymond Leong (PrimaNexus) |
10.30 AM – 11.00 AM |
Coffee Break and Poster Viewing |
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11.00 AM – 11.45 AM |
Basic principles of stereotaxic approach in experiments |
A/P Dr Igor Iezhitsa Ph.D. (Russia), Dr. Sci. Biol. (Russia) |
11.45 AM – 12.00 AM |
PARTICIPANTS AND FACILITATORS MOVE TO NEURON |
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12.00 AM – 13.00 AM |
Demonstration and hands-on stereotaxic approach in experiments |
Noor Azliza Wani Abd. Aziz, Mohd Aizuddin Bin Mohd Lazaldin |
13.00 – 14.00 |
Lunch |
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14.00 AM – 15.00 AM |
Demonstration and hands-on stereotaxic approach in experiments |
Noor Azliza Wani Abd. Aziz, Mohd Aizuddin Bin Mohd Lazaldin |
15.00 AM – 16.30 AM |
Demonstration on Behavioral Tasks Commonly Used for Testing Hippocampal-Dependent Cognition |
Noor Azliza Wani Abd. Aziz, Mohd Aizuddin Bin Mohd Lazaldin |
16.30 – 17.00 |
CLOSING REMARKS, TEA AND END OF DAY 2 |
DAY 3 EXPERIMENTAL MODELS OF GLAUCOMA (Fri 23/11/2018)
(Anchored and chaired by Dr Renu Agarwal)
TIME |
TITLE |
SPEAKERS / FACILITATORS |
8.00 AM - 8.30 AM |
Registration |
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8.30 AM - 8.40 AM |
Welcome address and introduction to workshop |
Prof Dr Renu Agarwal Faculty of Medicine, UiTM |
8.40 AM - 9.15 AM |
Research in glaucoma: needs and challenges |
A/P Dr Puneet Agarwal |
9.15 AM - 10.00 AM |
Animal models of glaucoma |
Prof Dr Renu Agarwal |
10.00 AM - 10.30 AM |
TEA BREAK |
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10.30 AM - 11.15 AM |
Ethical considerations in animal research |
Prof Dr Harbindarjeet Singh |
11.15 AM -11.30 AM |
PARTICIPANTS AND FACILITATORS MOVE TO NEURON |
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11.30 AM - 12.30 PM |
Hands on: General ophthalmic examination in rats and IOP estimation |
Adrian/ Dr Norhafiza Razali |
12.30 PM - 2.30 PM |
LUNCH |
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2.30 PM – 3.15 PM |
Hands on: enucleation, isolation of ocular tissue including retina, |
Lidawani and Azliana |
3.15 PM – 3.30 PM |
PARTICIPANTS AND FACILITATORS MOVE TO IMMB |
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3.30 PM – 4.30 PM |
Retinal flat mount preparation. |
Natasha Najwa |
4.30 PM |
CLOSING REMARKS, TEA AND END OF DAY 3 |
REGISTER HERE